Mme March stands as the resilient matriarch of the March family during the American Civil War. With her husband away serving in the military, she shoulders sole responsibility for raising their four daughters—Meg, Jo, Beth, and Amy—in Concord, Massachusetts. She exhibits resilience managing the household independently while nurturing her children.

Her compassion extends beyond her family, driving her active participation in charitable efforts aiding families impacted by the war, reflecting a socially conscious mindset aligned with the family's opposition to slavery and support for abolitionist causes. Emotionally perceptive moments define her, like stealing quiet moments on Christmas Eve to check her sleeping daughters by candlelight, expressing silent gratitude for them despite hardships.

Her guidance consistently shapes her daughters' moral growth. She encourages their decision to sacrifice personal Christmas gifts to assist her and supports their initiative to share breakfast with a destitute neighboring family after the mother gives birth. Her parenting balances discipline with emotional support, particularly during conflicts like those between Jo and Amy.

Significant narrative moments include her involvement in selecting a foster daughter. Her leadership stabilizes the household through periods of tension, such as Beth's life-threatening illness and the arrival of ominous telegrams concerning family members. The series concludes with her continuing presence as a unifying force during the family's transition into spring, symbolizing enduring maternal strength amid change.