Nene Hampden belongs to the affluent capitalist Hampden clan of the Imperial Capital. At twelve years old, she attended the Imperial Capital Youth Academy with Nanoca Flanka, whom she holds in high regard; Nene was responsible for recommending Nanoca undertake the mission to restore Tristia.

Nene demonstrates persistent admiration for Nanoca, frequently expressed through physical affection like hugging her during reunions or after events such as golem tournaments. She consistently clings to Nanoca's arm in public settings like amusement parks. Nene exhibits pronounced possessiveness and jealousy regarding Nanoca's interactions. She flares with anger witnessing Reygurett Kutanie cuddle Nanoca and reacts with intense jealousy when Rafarew assists Nanoca during bath time, an opportunity Nene initially sought.

She maintains a rivalry with Faury Carat, particularly centered around feeding or caring for Nanoca. Nene frequently worries about Nanoca's physical well-being; even haunting daydreams depicting Nanoca in distress cause her significant anxiety. During Nanoca's mechanical golem competitions, Nene watches with visible excitement, eyes sparkling. Her focus remains consistently oriented toward Nanoca's activities and welfare across all documented interactions. Her core traits remain consistent throughout documented interactions.