Yukiko Mio, a patient at Morita Hospital battling a kidney ailment, undergoes a transplant from Tomie Kawakami that briefly improves her health. The donated kidney inexplicably regenerates into Tomie’s severed head within her abdomen, forcing emergency removal. Lingering cells from the organ persist in her system, sparking insidious physical and mental alterations. Her brown hair shifts to sleek black, while a distinctive beauty mark materializes beneath her left eye. Her stature increases, her appearance sharpening into conventional attractiveness as her personality warps into vanity, biting sarcasm, and disdain for former confidants like her boyfriend Tadashi. These mutations escalate upon encountering Fumihito Sato, a visitor immune to her emerging charms. His preference for her past self fuels her spite, heightening her cruelty. Tomie’s residual cells ultimately overtake Yukiko’s biology and mind. Amid a hospital fire, she sheds her identity entirely, emerging as a Tomie duplicate who claims Tomie’s name and traits yet faintly recalls her original life. She spares Fumihito during her escape, referencing his prior compassion before vanishing. Later reports link her medical team to mysterious fatalities, while her own destiny stays unconfirmed.