"Junji Ito Collection: Tomie" is an anime adaptation of Junji Ito's iconic horror manga series, focusing on the enigmatic and malevolent character Tomie Kawakami. The story revolves around Tomie, a strikingly beautiful and mysterious girl who exerts an unnatural influence over those around her. Her presence incites obsession, jealousy, and violence, often leading to gruesome and tragic outcomes. Despite her apparent death in various instances, Tomie inexplicably reappears, perpetuating a cycle of horror and destruction.

The narrative is episodic, with each segment exploring different encounters with Tomie and the chaos she brings. In one story, a high school classmate becomes consumed by jealousy over Tomie's beauty, leading to a descent into madness and murder. In another, a doctor becomes obsessed with Tomie after treating her, only to discover her regenerative abilities and the horrifying consequences of her immortality. Tomie's ability to manipulate and corrupt those around her is a recurring theme, as her victims often lose their sanity or meet violent ends.

Tomie herself is portrayed as both alluring and terrifying, embodying a supernatural force that defies explanation. Her beauty is otherworldly, but it masks a malevolent nature that drives people to extremes. The series delves into the psychological and physical horrors inflicted by her presence, with each episode offering a new perspective on her destructive influence. The animation style captures the eerie and unsettling atmosphere of Ito's original work, emphasizing the grotesque and surreal elements of the story.

The supporting characters vary across episodes, each serving as a vessel to explore Tomie's impact. They range from classmates and lovers to professionals like doctors and artists, all of whom fall under her spell in different ways. Their interactions with Tomie reveal the depth of her manipulative power and the inevitability of their downfall. The series maintains a consistent tone of dread, with each episode building on the pervasive sense of unease that defines Tomie's world.

Overall, "Junji Ito Collection: Tomie" presents a chilling exploration of beauty, obsession, and the supernatural, staying true to the source material's themes and tone. The episodic structure allows for a variety of horror scenarios, all tied together by the enigmatic and malevolent presence of Tomie Kawakami.