Shiko Murasame fights alongside the Tokyo Branch of the HxEros team against extraterrestrial Censor Bugs that drain human erotic energy (H-energy). Her appearance features tan skin, bushy white hair, and a medical eyepatch covering her right eye. This eyepatch is integral to her XERO gear, which medically manages her physiological condition. Because her entire body functions as an erogenous zone, the gear desensitizes her, significantly reducing physical sensations as a side effect.

Personality-wise, Shiko exhibits a teasing and encouraging nature, especially regarding sexuality. She notably greeted with approval an instance of boys attempting to look up her skirt, reflecting her comfort and encouragement of such behavior. Her role in HxEros requires harnessing H-energy for combat, though her near-total sensory numbness complicates this ability. Physical contact with Retto Enjō, a member of the Saitama Branch, uniquely sparks sensation within her and enables her to generate H-energy. This specific physiological response fuels her intense attraction to him.

Her relationship with Retto forms a core aspect of her character. She explicitly states a desire to "make him hers," frequently justifying this pursuit as necessary for H-energy replenishment. Despite this framing, she actively employs unapologetically seductive tactics to achieve intimacy with him. This includes direct efforts to undermine his existing connection with Kirara Hoshino, positioning herself as a romantic rival.

Her documented role centers on interactions with the Saitama Branch members, particularly Retto, and her participation in missions as part of the Tokyo team.