Nanae Fudō leads Nought, a performance group showcasing individuals with supernatural Incomprehensible Skills of Human beings (ISH). Though possessing ISH abilities herself, she voluntarily suppressed them. Her core drive is forging a world where ISH users and non-users coexist peacefully, establishing Nought to promote understanding through magical performances.

She profoundly impacted Amane Todoroki, inspiring her to join Nought. This mentorship began when Nanae intervened to protect Amane after the girl accidentally unleashed her twin sister Lilianne's full ISH power. Nanae's guidance shaped Amane's path within the group.

During a confrontation with Aya of rival group IAM, Nanae aided Amane and Lilianne. After the twins fused their powers to reach Aya's shielded physical form – trapped behind defenses fueled by childhood persecution trauma due to her ISH – Nanae contributed her capabilities to disrupt this barrier. This act liberated Aya from her past, leading to reconciliation. Aya subsequently abandoned IAM and joined Nought under Nanae, aligning with her vision of unity.

Nanae Fudō's actions consistently demonstrate her commitment to coexistence and her protective role towards Nought's members, particularly Amane.