Joe, an ordinary movie enthusiast, frequents his father's theater idolizing the superhero Captain Blue. During a date with girlfriend Silvia, a villain bursts from the screen, defeats Captain Blue, and kidnaps Silvia into Movieland. Captain Blue's mecha, Six Majin, pulls Joe into this cinematic realm where Blue grants him a V-Watch. Declaring "Henshin-a-Go-Go, Baby!" transforms Joe into the superhero "Viewtiful Joe."
Initially focused on rescuing Silvia, Joe discovers she possesses the "DNA of the Creator," vital for the villains' plan to invade the real world. His quest pits him against Jadow organization members: Charles the 3rd, Hulk Davidson, Gran Bruce, the doppelgänger "Another Joe," and Alastor—who dubs him "Viewtiful Joe" upon witnessing his combat prowess. The conflict culminates in Captain Blue's betrayal, revealed as Silvia's father and Jadow's mastermind. After defeating Blue, Joe and Silvia reconcile with him. Silvia gains her own V-Watch, transforming into a superheroine to fight alongside Joe against new threats.
Joe's abilities stem from "VFX Powers": "Slow" decelerates time to amplify attack strength and reflexes; "Mach Speed" accelerates movement, creating fiery afterimages for rapid assaults; "Zoom In" focuses the camera, enhancing attacks while increasing damage taken. These powers drain the VFX Gauge, replenished by VFX Juice or natural recovery. His arsenal includes the Voomerang (a boomerang-like projectile), Shocking Pink (a kickable bomb), and the Red-Hot Kick (a multi-directional aerial divekick). He pilots the transforming aircraft Six Machine and later commands Six Majin.
His transformation requires an audience or camera focus to inflate his ego, a limitation overcome when Silvia films him with her V-Cam. Personality-wise, Joe evolves from a fanboyish "Idiot Hero" to a more responsible figure, retaining theatrical flair, catchphrases like "Too slow!" during dodges, and a love for cheeseburgers. His film knowledge grants Genre Savvy, aiding puzzle-solving and combat. Despite occasional flirtations frustrating Silvia, their relationship solidifies into a Battle Couple dynamic. Joe exhibits fierce loyalty, with threats to friends or Silvia triggering intense retaliation.
His family includes father Jet, mother Junko, and sister Jasmine—all names starting with "J"—later extending to Silvia's family, including Captain Blue. He forms a "Badass and Child Duo" with Captain Blue Jr. and displays technical skill repairing the android Miss Bloody Rachel.