The narration in adaptations of "Run, Melos!" serves as an omniscient third-person voice, recounting events without direct involvement. It maintains a consistent perspective across all media, chronicling Melos's journey from arrest by King Dionysius to his desperate race against time to save his friend Selinuntius. This narration details Melos's physical and psychological struggles, including natural obstacles, bandit attacks, and moments of doubt where he nearly abandons his mission.

In the Aoi Bungaku Series adaptation, the narration explicitly contrasts external events with characters' internal monologues. This technique separates Selinuntius's anxious waiting from Melos's exhausting run, heightening tension through juxtaposition. It poses thematic questions, such as whether waiting or being waited for causes greater suffering, framing the characters' dilemmas.

A 2023 print media project experimented with the narration's form through distinct visual treatments. The main narrative text printed sideways via laser printing required readers to rotate the book 90 degrees—a design mirroring Melos's arduous journey. Inner monologues and character thoughts were overlaid using risograph printing in yellow ink, creating a tactile distinction between objective narration and subjective perspectives.

The narration remains neutral regarding character motivations. It recounts Melos's initial assassination plan without endorsement or condemnation and describes the king's cynicism objectively. During the climax, it dispassionately reports the crowd's reaction and the king's change of heart without moral judgments.

Across all media, the narration emphasizes perseverance and the human capacity for trust. It methodically details every obstacle Melos faces—overflowing rivers, broken bridges, physical collapse—highlighting endurance. Its structure culminates in the reunion scene, where the friends' mutual apology and the king's transformation resolve the central conflict concerning faith in humanity.