Seth manifests as a trickster deity dedicated to persistent pranks, chiefly targeting Horus. His elaborate antagonistic schemes employ disguises and disruptive behavior, consistently foiled by interventions from Horus’s assistant Otter or other circumstances. A notable incident involves Seth adopting a phantom thief persona to steal a rare gem, countered by Horus acting as a detective and Thoth embodying a magical girl archetype.

Socially, Seth exhibits chaotic tendencies like placing excessively complicated food orders at Horus’s restaurant to cause delays. Despite these actions, he participates in group activities with fellow Egyptian gods, including New Year banquets and talent shows.

His character design incorporates traditional iconography—a distinct animal head with a curved snout and tall, square-tipped ears—rendered in a stylized, cute aesthetic consistent with the series’ approach to deities.

Regarding development, Seth transitions from a background presence in Season 1 to prominent roles in Season 2. This includes reconciling with Thoth after a hypnosis-induced conflict and engaging in communal activities like pizza sharing, signaling gradual integration into the group despite his mischievous nature.

Modern adaptations feature Seth utilizing technology and social media platforms like "Egystagram," aligning with the series’ incorporation of contemporary elements into divine daily life.