Fujiko Mine operates as a professional thief and confidence trickster, renowned for shifting alliances and expert deception. In *The Columbus Files*, a cliffside accident triggers trauma-induced amnesia, temporarily replacing her seductive confidence with timidity and vulnerability. Despite losing memories of her criminal past, she instinctively wields firearms and executes evasive maneuvers, remnants of muscle memory from her career.
Her history intersects with organized crime, including a covert stint as an assassin alongside syndicate partner Killer Poon—a past she obscures by citing amnesia for events preceding her entanglement with Lupin III. Relationships with Lupin, Jigen, and Goemon oscillate between betrayal and reluctant collaboration, though Lupin persistently pardons her schemes, embracing her unpredictability as integral to their dynamic.
Within *The Columbus Files*, her amnesia intertwines with the hunt for the Columbus Egg, a mythical artifact linked to weather-controlling "Olgon Energy." While vulnerable, she becomes a target for rival factions, dependent on treasure hunter Rosaria for aid. Recovery emerges through confronting traumatic accident flashbacks, culminating in reclaiming her identity by accepting Lupin’s hand during a climactic showdown.
Proficient in firearms, martial arts, multilingualism, and vehicular piloting, she weaponizes disguises and allure to manipulate adversaries or evade capture. Moments of vulnerability—claustrophobia, fear of aging—puncture her otherwise calculated exterior.
Franchise continuity frames her as a mercurial figure, alternating between ally and antagonist. Early iterations featured multiple Fujikos with divergent roles, later unified into a single morally ambiguous entity. Her visual design shifts across narratives—hairstyles, attire, and hair color adapting to tone—while her brown eyes remain a constant.
Spin-offs like *Farewell to Nostradamus* and *The Woman Called Fujiko Mine* delve into her identity through nonlinear storytelling, exploring manipulation and hinted fluid sexuality, though her motivations stay rooted in pragmatic self-interest.