Senku Ishigami, a scientifically gifted individual adopted by Byakuya Ishigami, developed an early fascination with space exploration and science. Influenced by childhood dreams and series like Doraemon, he conducted experiments from a young age, constructing functional miniature rockets and specialized equipment such as a swimsuit to aid Byakuya's astronaut training. During his youth, he corresponded with a scientist later known as Dr. Xeno, seeking guidance on complex projects. Before the global petrification event, Senku attended high school with friends Taiju Oki and Yuzuriha Ogawa. He assisted Taiju in romantic pursuits while displaying characteristic logical and occasionally manipulative tendencies.
Trapped during the petrification event that turned humanity to stone for approximately 3,700 years, Senku retained consciousness and meticulously counted every second. Environmental nitric acid dissolved his stone shell, causing his revival on April 1, 5738. He immediately established survival necessities, documented the date, and researched depetrification methods. Discovering that nital (nitric acid and ethanol) could reverse petrification, he revived Taiju. Together, they revived Yuzuriha and Tsukasa Shishio, a formidable martial artist. Tsukasa opposed Senku's goal of restoring modern civilization, deeming it corrupt. After extracting the revival formula, Tsukasa attempted to kill Senku. Senku survived due to residual petrification protecting his neck, faked his death, and fled with Taiju and Yuzuriha.
Senku encountered Ishigami Village, founded by descendants of Byakuya and other International Space Station astronauts who avoided petrification. Initially met with skepticism, he gained the villagers' trust through scientific innovations like antibiotics, ramen, and eyeglasses, significantly improving their quality of life. He became village chief after winning the Grand Bout tournament. Forming the Kingdom of Science, he mentored villagers like Chrome and Kohaku, integrating their skills with his scientific knowledge. This group opposed Tsukasa's Empire of Might, sparking the Stone Wars. Senku's strategies, featuring non-lethal weapons and psychological tactics, culminated in Tsukasa's defeat. A truce was secured by reviving Tsukasa's sister, Mirai.
Post-conflict, Senku led global exploration to uncover the petrification's origin. He revived Ryusui Nanami for navigational expertise, enabling sea voyages. Discoveries on Treasure Island revealed the "Medusa" device responsible for petrification, controlled by the antagonistic Why-Man. Senku's group recovered precious stones from a Soyuz capsule, enabling mass revivals. Subsequent expeditions, including a voyage to South America, involved confrontations with his former mentor, Dr. Xeno, who possessed advanced technology and hostile intentions. These events tested Senku's adaptability, leading to alliances with former adversaries like Tsukasa and Hyoga to counter new threats.
Senku's personality is defined by relentless logic, curiosity, and commitment to scientific progress. He frequently uses catchphrases like "ten billion percent" to express certainty and "get excited" during discoveries. Outwardly arrogant and manipulative—withholding information or bending rules to achieve goals—he demonstrates deep loyalty, risking his life for allies and mourning losses like Byakuya's death. He dismisses romance as illogical, quickly divorcing Ruri after a strategic marriage and rejecting advances from characters like Kohaku or Amaryllis, but supports relationships among friends. His physical frailties contrast with mental resilience; he ranks low in combat strength compared to warriors like Kohaku and relies on others for protection. Key weaknesses include overlooking variables like Earth's axial precession, average craftsmanship compared to specialists like Kaseki, and vulnerability to environmental hazards like hypothermia.
Senku possesses encyclopedic scientific knowledge across chemistry, physics, engineering, and biology, enabling inventions like generators, communication devices, and revival fluid within resource-limited environments. He is fluent in Japanese and English, proficient in Morse code, and skilled in tactical planning, evidenced by successful infiltrations and large-scale coordination during conflicts. His leadership inspires unwavering loyalty, turning adversaries into allies through charisma and demonstrable benefits of science. Central relationships include Taiju and Yuzuriha as childhood confidants, Chrome as his scientific apprentice, and Tsukasa as a philosophical rival turned reluctant collaborator. Petrifaction scars on his face, initially jagged lines from eyebrow to hairline, healed after revival within a rocket.
Recent developments involve Senku's role as one of the Five Wise Commanders, coordinating global efforts to confront Why-Man. Expeditions continue into unknown territories, utilizing advanced vessels and confronting threats like Dr. Xeno's faction. The ongoing mission focuses on understanding and neutralizing the petrification phenomenon while rebuilding a sustainable scientific society.