Inspector Juzo Megure, a high-ranking officer within the Tokyo Metropolitan Police Department, spearheads the investigative response to Arsène Lupin III's activities during the Cherry Sapphire theft. He coordinates police operations to apprehend the thief and secure the targeted gemstone, overseeing security measures and directing personnel including Miwako Sato and Wataru Takagi. Megure leverages his established professional relationship with Interpol inspector Koichi Zenigata, drawing on their past collaboration to advance the investigation into Lupin. This coordination facilitates Kogoro Mouri's official involvement as Zenigata's assistant. When threats emerge against singer Emilio Baretti during a stadium concert, Megure directs on-site security protocols and suspect interviews, with his team managing crowd safety and addressing the danger to Baretti. His investigative approach emphasizes procedural diligence, relying on established police resources and personnel during complex operations like surveillance at transportation hubs where criminal activities intersect. Megure possesses decades of operational police experience, marked by a past head injury that left a concealed scar and necessitates his consistent wearing of a hat during public appearances. Professionally, he associates with detective novelist Yusaku Kudo, whose insights Megure historically valued during difficult investigations. This connection provided early exposure to Yusaku's son, Shinichi Kudo, whose later detective work Megure came to respect. During the Cherry Sapphire case, his interactions with Conan Edogawa remain professionally distant, reflecting his typical view of child investigators as potential impediments until they demonstrate substantive contributions. Collaboration occurs between Megure's team and Lupin's associates during the case's resolution phase, specifically when Fujiko Mine and Ai Haibara secure essential transportation. This operational overlap unfolds without direct coordination between Megure and the Lupin group.