Nodoka Hanadera is a calm, optimistic second-year middle school student who lives life at her own pace. Driven by a strong desire to help others despite lacking athletic skill—a trait partly rooted in a childhood illness caused by the Megabyogen parasite Daruizen, leading to prolonged hospitalization—she developed deep empathy and determination to protect. Her appearance features dark pink eyes and chin-length auburn hair, typically held with side clips, one decorated by a pink flower. She favors light-colored outfits like white blouses layered with light blue and pink pleated skirts.

Transforming into Cure Grace, the Pretty Cure of Flowers, her eyes and hair brighten to pink, growing longer and wavier, often styled in a bun adorned with flowers and a pearl hairpiece featuring a dark pink heart, green leaf, and yellow flower. Her attire shifts to layered flower-shaped skirts in fuchsia, lilac, and pale pink, a scalloped top, and a pale pink jacket with heart-shaped details, completed by white gloves and ankle-strapped shoes. As Cure Grace, she wields the Healing Stick alongside Element Bottles for attacks like "Healing Flower," firing a petal-shaped ray by drawing a heart, and group techniques including "Healing Oasis" and "Healing Partner Quartet."

Her relationships are pivotal. She partners with the fairy Rabirin, who overcame initial distrust of her physical weakness to respect her courage. She forms a deep bond with Latte, the Healing Garden princess, relating to her vulnerability to illness. Close friendships include athletic Chiyu Sawaizumi (Cure Fontaine) and cheerful Hinata Hiramitsu (Cure Sparkle). She also hosts Asumi Fuurin (Cure Earth), viewing her as an older sister. The antagonist Daruizen, revealed as the parasite born from her childhood infection, is ultimately rejected in his attempts to re-infect her.

Cure Grace accesses multiple advanced forms. In *Miracle Leap*, encountering the spirit Miraclun ("tomorrow") pursued by Refrain ("yesterday") within a repeating time loop, she coordinates with *Hugtto!* and *Star Twinkle* Pretty Cure teams to protect Miraclun. Using Miraclun Light energy, she becomes Super Miracle Grace (or Super Cure Grace): her hair gains volume with a pale pink-to-orange ombré, and her outfit features a sakura flower headpiece, translucent sleeves, elongated gloves, and layered petal skirts. Wielding the Miracle Leap Element Bottle, she performs "Healing Time Liberation," firing a pink-and-white tornado to purify Refrain and free Miraclun, resolving the time anomaly and preserving their home—a school tied to Nodoka's past.

Additional forms include "Special Healin’ Good Style," granting thigh-length hair, a physician-like gown with angel wings, and participation in the group attack "Final Healin’ Good Shower"; "Rabirin Grace" (Partner Form), featuring bunny ears and a fuchsia kimono for "Healing Partner Quartet"; and "Dream Cure Grace," achieved with Cure Dream in a crossover film, characterized by butterfly motifs and a white dress. Her character consistently embodies themes of healing, resilience against stagnation, and protecting connections between past and future.