Nurse Joy recurs throughout the Pokémon franchise as a medical professional dedicated to Pokémon care. She is part of a large family where every member shares identical appearances, voices, and personalities across different locations, often leading to confusion that they are one person despite being distinct relatives. Minor differences, such as varying hat cross colors or subtle physical traits, allow individuals like Brock to tell them apart. While most work as nurses in Pokémon Centers, some Joys hold other lawful positions like investigators or inspectors. They consistently exhibit kindness, patience, and healing dedication.

In *Pokémon the Movie: Kyurem VS. The Sword of Justice*, Nurse Joy runs the Pokémon Center in Roshan City. When Ash and his friends bring the injured Keldeo, she provides medical treatment to restore it. During this care, she identifies Keldeo and recounts the Swords of Justice legend involving Terrakion, Virizion, and Cobalion. She narrates how these three intervened during a human-conflict forest fire: Terrakion carved escape routes, Virizion shielded fleeing Pokémon with speed, and Cobalion guided them to safety. Afterwards, they discovered and adopted the orphaned Keldeo in the burned forest remains. Nurse Joy further explains that Keldeo must defeat Kyurem to officially join the Swords of Justice, clarifying its motivations.

Her film role aligns with her established profession: administering care to injured Pokémon and supplying trainers with essential information. She uses her Audino, a Pokémon skilled in nursing others back to health, for medical support. This partnership reflects a regional variation, as Nurse Joys in Unova (where Roshan City is located) typically employ Audino instead of the Chansey or Blissey common elsewhere. Differences in her appearance and hat symbol compared to other regions stem from cultural distinctions and intentional visual updates.