Misa Kakizaki attends Mahora Academy in Class 2/3-A, serving as captain of the cheerleading squad where she leads Madoka and Sakurako, and also participates in the chorus club. Physically, she stands 165 cm tall, weighs 74.6 kg, with measurements B82-W58-H84. She possesses purple hair and reddish-brown eyes in the anime adaptation, though earlier media depicted her with brown hair. Her personality displays a mature inclination compared to classmates, notably demonstrated by her "reverse Hikaru Genji" plan. This strategy involves intending to "educate" her young teacher, Negi Springfield, into a future romantic partner after witnessing a red-haired man resembling Negi's father at a festival. She refers to herself as "onee-san" around Negi. She enjoys shopping, prunes, and karaoke, but dislikes carbonated drinks. She holds the distinction of being the only student in her class confirmed to have a steady boyfriend, though his identity remains unseen and unnamed throughout the series; speculation suggests he might be a self-insert of series creator Ken Akamatsu, based on Akamatsu's stated preference for forming a Pactio with her. Within the main storyline, she is among the last students to learn about magic, discovering it during the sports festival months after the magical world arc. She participates in events like the "Mars vs. Mages" game, where energy beams from robots strip her to her underwear. This experience prompts self-reflection on her potential attraction to the much younger Negi, leading to suggestions she might share Ayaka Yukihiro's shotacon tendencies. She later assists Negi in rescuing his father, Nagi Springfield, and defeating the Mage of the Beginning. Following the main events, she works as a concierge at the Station Hotel within the continually developing Mahora City. Her responsibilities increase alongside Mahora's growth, eventually including service to non-human guests. Despite concerns from Negi and others, she finds this work enjoyable. In the alternate continuity *Negima!?*, her portrayal differs. The cheerleading trio often speak in unison or finish each other's sentences. During the "Suka incident," she transforms into a goat. Her Pactio artifact manifests as a cabaret dancer costume with a key necklace and arm pompoms in one form, and as armor based on Yuma Kazama from *Sukeban Deka*, wielding knitting needles, in another. She also appears in video games like *CR Mahou Sensei Negima!* and the upcoming *Mahou Sensei Negima! Mahora Panic*.