Makiko Gregory is a half-British, half-Japanese university student with waist-length blonde hair and blue eyes. Her typical attire of a coat and turtleneck reinforces her elusive and reserved demeanor.

Academically, she is a diligent and talented student who excels, particularly in abnormal human physiology. She maintains high performance and earns respect from peers and instructors despite personal struggles.

Outwardly quiet and observant, often keeping to herself, Makiko possesses internal complexity. She harbors a dark, obsessive fascination with bodily fluids and waste products, leading to behaviors like secretly drinking her own urine. These tendencies cause significant internal conflict and social alienation.

Her relationships feature a codependent dynamic with another student, Yesterday Taguchi, whom she assists. This connection highlights her loyalty and willingness to support others, even when it places her in uncomfortable situations.

Throughout her story, Makiko faces ostracism, ridicule, and bullying from classmates due to her unconventional behaviors. Despite this social pressure, she refuses to conform or let others' judgments define her. She persists in her academic pursuits and continues exploring taboo aspects of human physiology.

Makiko's development involves ongoing efforts to reconcile her desires with societal expectations while coping with isolation. She confronts her inner conflicts without seeking external validation, maintaining focus on her intellectual interests as she battles personal demons. No narrative redemption arc or significant alteration in her fundamental traits occurs across available media.