Dr. Serene works as a scientist at the laboratory where Team Astro operates alongside Professor Elefun and Dr. Blunt. She conducts scientific studies and experiments at this facility, demonstrating expertise in botany, irrigation systems, and miniaturization technology. Her experiments include developing specialized ivy plants and innovative irrigation methods, while her notoriously poor cooking skills serve as a recurring comedic element—her homemade meatballs once diverted an asteroid, and her irrigation design inspired a solution to redirect volcanic lava.

Dr. Serene actively supports Team Astro's missions by monitoring field operations and providing technical assistance. She collaborates closely with fellow scientists, such as aiding Dr. Blunt during a telepathy experiment involving a chinchilla. Despite personal anxieties like her fear of Dr. Blunt's octopus Simone, she remains composed and professional during crises. Her scientific contributions extend to creating technologies like micro-robotic suits for miniaturization missions.

Through her work, Dr. Serene emphasizes environmental problem-solving and coexistence with nature, consistently developing experiments and inventions that assist Team Astro in addressing global ecological challenges.