"Go Astro Boy Go!" is a children's anime series that reimagines the classic Astro Boy character in a simplified, lighthearted format aimed at younger audiences. The story centers on Astro, a cheerful and energetic robot boy with a strong sense of justice and a desire to help others. Alongside his friends, Astro embarks on various adventures to protect his city and its inhabitants from everyday challenges and occasional threats. The series emphasizes teamwork, problem-solving, and kindness, with each episode presenting a self-contained story.

Astro's primary companions include his sister, Astro Girl, a resourceful and intelligent robot who often assists in solving problems, and Dr. Ochanomizu, their creator and mentor, who provides guidance and support. The group frequently encounters a trio of mischievous robots—Hamegg, Atlas, and Cobalt—who, despite their antics, are not truly malicious and often find themselves in humorous situations. The dynamic between Astro and these characters adds a playful tone to the series, balancing its moral lessons with lighthearted entertainment.

The narrative structure is episodic, with each episode focusing on a specific challenge or conflict. These range from rescuing citizens in danger to addressing environmental issues or thwarting minor threats posed by the mischievous trio. The series avoids complex story arcs, opting instead for straightforward, easily digestible plots that reinforce positive values such as friendship, perseverance, and responsibility. The simplicity of the storytelling makes it accessible to its target audience while retaining the core themes of the Astro Boy franchise.

The setting is a futuristic city where humans and robots coexist, often highlighting the importance of harmony between the two. The series incorporates elements of science fiction, such as advanced technology and robotic characters, but keeps these concepts approachable for younger viewers. The tone remains consistently upbeat, with a focus on action, humor, and moral lessons, ensuring that each episode delivers an engaging and educational experience.