Professor Serena works as a scientist and assistant at the AstroLab alongside Dr. Ochanomizu and Dr. Blunt. Her role involves conducting scientific experiments and developing technological solutions for environmental challenges. She develops inventions like an experimental irrigation system later adapted to divert volcanic lava flows and a cold remedy that produces unintended effects when encountered by miniaturized characters.

Her experiments sometimes lead to complications, including an underground rescue mission where her actions involve confronting phobias, specifically her own apprehension toward an octopus named Simone. On another occasion, her homemade meatballs unexpectedly aid in averting an asteroid collision.

Professor Serena participates in team activities, such as a scenario where Dr. Ochanomizu stages his own kidnapping to test deductive abilities, though her specific role remains undetailed. She exhibits a blend of scientific dedication and humanizing traits, including imperfect cooking skills and specific fears.