Cheryl makes her only appearance in Episode 10, "The Old Chateau," of the animated series. She possesses long dark green hair arranged in a segmented ponytail, light gray eyes, and slightly pale skin. Her outfit features a light green and white semi-jacket layered over a brown undershirt, a dark green pleated skirt, and tall brown boots with low heels. Her animated design presents an hourglass figure and softer facial features than her original game depiction.

Accompanied by her Chansey, she seeks nighttime shelter in Eterna Forest’s Old Chateau, a location locally reputed as haunted. An elderly butler invites them inside, where they witness disturbing paranormal activity: a purple-faced ghost girl manifests, and the butler’s form twists menacingly. These phenomena trap Cheryl and Chansey within an isolated haunted dimension of the mansion.

Throughout the episode, Cheryl displays consistent fear and vulnerability. Escalating hauntings culminate in a confrontation with a ghost—possibly Rotom, suggested by comparable eye designs—that corners them. The episode concludes ambiguously without resolving their fate. This sequence may chronologically precede her game request for an escort through Eterna Forest or portray a darker outcome following that encounter.

Chansey remains her sole documented Pokémon during these events, demonstrating loyalty while unable to counter their supernatural imprisonment.