Shinichi Kuruma, son of cult-leading scientist Dr. Genzou Kuruma, inherits a legacy of twisted ambition. His father’s experiments, designed to awaken a deity through genetically altered beings, claimed Shinichi’s mother and imbued him with monstrous gifts: the power to summon combat manifestations of a lion, bear, and hawk from his body. These abilities arise from "Almighty Cells" engineered by Genzou, granting Shinichi enhanced strength and rapid regeneration.

Surviving the ordeal forged Shinichi into a vengeful force against his father, who persists in crafting "New Humans"—hybrids merging human and monstrous traits. In one timeline, his bond with Maria Tengai, a woman entwined with religious symbolism, culminates in her death in his arms, triggering the cataclysmic "Great Destruction" and fueling his crusade against the cult. Another reality sees him psychically linked to Ayaka Sanders, a girl rescued by stem cells from his blood. Her capacity to produce the cult-coveted "blood of Maria" marks her as a target, entangling Shinichi in her defense.

His battles span foes from dinosaur-like New Humans to marine hybrids and clones of the cult’s god, each confrontation testing his struggle to restrain the feral instincts threatening his humanity. A pivotal clash pits him against Noah, a clone infused with Maria’s blood, embodying dualities of mercy and divine fury. Allies like Tomisaburou Tengai, who foreshadows looming threats, and his guarded alliance with Ayaka underscore his fractured ties to others—wavering between solitary vengeance and uneasy cooperation.

Expanded narratives, including the manga sequel *Shinsetsu Majuu Sensen*, resurrect Shinichi a decade post-conflict to face a resurgent apocalypse led by a "War God" and its disciples, delving deeper into his eternal role as a warrior against annihilation. His existence remains a tapestry of vengeance, experimental trauma, and morally gray choices, forever shadowed by the deity his father sought to unleash.