Alisa, also known as Arisa, features across multiple franchise adaptations as a subordinate and henchwoman to Akiko Natsume, executive of Mishima Heavy Industries. Her primary function involves assisting Akiko in schemes to retrieve Akiko's son Ryunosuke or reclaim the android Nuku Nuku, utilizing military-grade technology or unconventional methods supplied by Mishima Industries.

She operates as part of a duo with another agent, Kyouko, frequently executing Akiko's plans. Their actions typically culminate in comedic failures or significant collateral damage, stemming from reckless weapon usage and impulsive behavior. In one OVA episode, financial frustration after budget cuts motivates them to sabotage Nuku Nuku's restaurant job.

Within the alternate universe spin-off *DASH!*, Alisa and Kyouko experience a notable change: an unspecified incident causes them to switch bodies. This leads to a personality shift where Alisa becomes more laid-back and less prone to violence, contrasting with Kyouko's increased aggression. Mishima Industries assigns them to capture the escaped Nuku Nuku, but their incompetence persists; hijacking a fighter jet on their first mission, they accidentally destroy it, incurring a massive debt that forces them to work without pay.

Alisa's background lacks detailed exploration across all media. Her loyalty to Akiko remains consistent, though her motivations are not explicitly defined. She provides comic relief through her interactions with Kyouko and her exaggerated ineffectiveness in antagonistic roles.