A teenage boy named Amenogawa Scarlet hides the horns he was born with while living alone with his younger sister, Rua. Scarlet is searching for a way to cure Rua of an illness that draws in misfortune. His search leads him to transfer to the 2 AM Academy, a school attended by the Neighbor Species, beings with a variety of different appearances. The academy is said to be a miracle school where any wish can be granted. The story follows Scarlet as he begins his new life at this supernatural institution, interacting with students from diverse tribes or species, all while hoping to use the school's power to save his sister. The narrative is an otherworldly supernatural school fantasy centered on fulfilling one's dreams.