"Oshiri no Ohime-sama" is a comedic fantasy manga that centers around Princess Teruhime, a young royal whose life takes an unexpected turn when she is cursed with a giant, sentient buttocks attached to her body. The curse is the result of a magical mishap involving a mischievous spirit, and it becomes the driving force of the narrative. The story unfolds in a whimsical medieval-inspired world where magic and absurdity coexist.

Princess Teruhime, despite her royal status, is portrayed as a kind-hearted and determined individual who refuses to let the curse define her. Her journey revolves around finding a way to remove the curse while navigating the challenges it brings. The sentient buttocks, named Oshiri, possesses its own personality and often complicates situations with its unpredictable behavior, creating a dynamic and humorous relationship between the two.

The plot progresses as Teruhime embarks on a quest to seek out magical solutions, encountering a variety of eccentric characters along the way. These include wizards, mythical creatures, and rival royals, each contributing to the series' comedic and fantastical tone. The narrative balances episodic adventures with an overarching goal, blending slapstick humor with moments of character growth and camaraderie.

Supporting characters play significant roles in the story. Teruhime’s loyal attendants, including her steadfast maid and a bumbling knight, provide both assistance and comic relief. Antagonists, such as jealous nobles and power-hungry sorcerers, add conflict and stakes to the narrative, often exploiting Teruhime’s curse for their own gain.

The manga’s humor is derived from its absurd premise, exaggerated character reactions, and situational comedy. Despite its lighthearted tone, the story occasionally touches on themes of self-acceptance and resilience, as Teruhime learns to adapt to her unusual circumstances and confront societal prejudices. The interplay between the fantastical elements and the characters’ emotional journeys creates a unique blend of comedy and heart.

Overall, "Oshiri no Ohime-sama" is a distinctive manga that combines fantasy, humor, and character-driven storytelling, offering a memorable and entertaining narrative centered around an unconventional premise.