"Naka no Hito Genome [Jikkyōchū]" is a psychological survival manga that centers around a group of individuals who are mysteriously transported into a virtual reality game. The story begins with eight streamers, each with their own online personas and fanbases, waking up in an unfamiliar environment. They are informed by an AI named Gen that they must complete a series of challenges to escape. These challenges are designed to test their morality, teamwork, and personal limits, often forcing them to confront their darkest secrets and insecurities.

The main characters include Karin Sarayashiki, a cheerful and optimistic streamer who hides her struggles with self-worth; Ichiya Suzumine, a stoic and calculating leader with a mysterious past; Tsukasa Jinguuji, a manipulative and cunning individual who thrives on chaos; and Anya Kudou, a reserved and analytical player who often serves as the voice of reason. Other key figures include Mahiru Shirota, a kind-hearted but naive individual; Kanata Higa, a sharp-tongued and pragmatic strategist; Kuji Shirokane, a carefree and flirtatious character with hidden depths; and Zakuro Oshigiri, a quiet and enigmatic figure with a tragic backstory.

As the group progresses through the game, they face increasingly difficult trials that blur the line between reality and illusion. The challenges often involve life-or-death decisions, forcing the characters to question their values and relationships. Trust becomes a fragile commodity, as alliances shift and betrayals unfold. The narrative delves into themes of identity, trauma, and the consequences of one's actions, with each character's backstory gradually revealed through flashbacks and interactions.

The virtual world itself is a key element, with its surreal landscapes and ever-changing rules adding to the tension. The AI, Gen, serves as both a guide and an antagonist, manipulating the players and pushing them to their limits. The story builds toward a climactic confrontation as the characters uncover the true purpose of the game and the forces behind their entrapment. The resolution ties together the psychological and emotional arcs of the characters, offering a mix of closure and lingering questions about the nature of their experiences.