"Nyankoi" is a romantic comedy manga series that blends elements of supernatural fantasy with slice-of-life storytelling. The narrative centers around Junpei Kousaka, a high school student who harbors a deep dislike for cats due to a childhood trauma. However, his life takes an unexpected turn when he accidentally angers a local cat deity. As punishment, Junpei is cursed with the ability to understand the language of cats. This newfound ability complicates his life, as he becomes entangled in the whims and demands of the feline population around him.

The story introduces Mikazuki Yuzuyu, a shrine maiden who serves the cat deity and becomes Junpei's guide in navigating his curse. Yuzuyu is accompanied by her talking cat, Nyamsus, who often provides comic relief and assists Junpei in understanding his predicament. Junpei's childhood friend, Kaede Mizuno, also plays a significant role in the story. Kaede is a cat lover and is unaware of Junpei's curse, which leads to humorous misunderstandings and romantic tension as Junpei tries to keep his secret hidden.

As the series progresses, Junpei's interactions with cats and humans alike lead to a series of comedic and heartwarming situations. The curse forces him to confront his fear of cats while also deepening his relationships with those around him. The narrative explores themes of friendship, love, and personal growth, as Junpei learns to appreciate the quirks of both the human and feline worlds. The balance between supernatural elements and everyday high school life creates a unique dynamic, making "Nyankoi" a lighthearted yet engaging read.