"Sasuga no Sarutobi" is a comedic manga series centered around Sarutobi Ayame, a high school student who is deeply in love with her classmate, Hanamura Daikichi. Despite her petite and delicate appearance, Sarutobi possesses extraordinary physical strength, which she hides to maintain her feminine image. This duality becomes a recurring source of humor as she navigates her daily life, often finding herself in situations where her strength inadvertently causes chaos or embarrassment.

The narrative explores Sarutobi's attempts to win Hanamura's affection while concealing her true abilities. Hanamura, oblivious to her feelings, often finds himself in awkward or comedic situations due to Sarutobi's overzealous efforts to impress him. The series also features a supporting cast of classmates and friends who contribute to the comedic dynamics, including Sarutobi's best friend, who is aware of her secret and often provides advice or assistance.

Throughout the story, Sarutobi's strength is frequently juxtaposed with her desire to be seen as a typical, gentle girl, creating a humorous contrast that drives much of the plot. The series balances slapstick comedy with moments of lighthearted romance, as Sarutobi's determination to win Hanamura's heart remains a central focus. The interactions between characters are marked by exaggerated reactions and misunderstandings, typical of the genre, which add to the overall comedic tone.

The manga maintains a light and episodic structure, with each chapter presenting new scenarios that highlight Sarutobi's struggles and her interactions with those around her. The humor often arises from the gap between her outward appearance and her hidden strength, as well as the misunderstandings that result from her attempts to keep her abilities a secret. The series does not delve deeply into dramatic or serious themes, instead prioritizing comedic situations and character-driven humor.