"Costume-Play Girls Strange Fxxking" is a manga series that blends elements of comedy, slice-of-life, and ecchi genres. The narrative centers around a group of young women who are passionate about cosplay and the unique challenges they face in their daily lives. The protagonist, a college student named Yui, is an avid cosplayer who often finds herself in humorous and awkward situations due to her hobby. Alongside her are her friends, each with distinct personalities and interests, who frequently join her in various cosplay activities.

The story explores the dynamics of their friendships and the lengths they go to in order to pursue their passion for cosplay. From attending conventions to creating intricate costumes, the characters navigate the complexities of balancing their personal lives with their dedication to the craft. The series delves into the behind-the-scenes aspects of cosplay, including the creative process, the challenges of perfecting a costume, and the social interactions that come with participating in cosplay events.

Throughout the series, the characters encounter a variety of comedic and sometimes surreal scenarios, often stemming from misunderstandings or the exaggerated nature of their situations. The narrative maintains a lighthearted tone, with occasional moments of introspection about the characters' motivations and the impact of their hobby on their lives. The manga also touches on themes of self-expression, identity, and the sense of community found within the cosplay subculture.

The main characters include Yui, the enthusiastic and sometimes clumsy leader of the group; Aya, a perfectionist who takes cosplay very seriously; and Miku, a shy but talented cosplayer who often surprises her friends with her creativity. Together, they form a close-knit group that supports each other through their shared experiences and the occasional chaos that ensues from their adventures in cosplay. The series provides a detailed and often humorous look at the world of cosplay, highlighting both the joys and challenges that come with it.