"Kitsune-san ni Bakasaretai!" is a manga series that blends elements of supernatural folklore with slice-of-life and romantic comedy. The narrative centers around a young man named Haruto, who encounters a kitsune, a mythical fox spirit from Japanese folklore, named Kitsune-san. Kitsune-san possesses the ability to shapeshift and often uses her powers to play pranks on humans, particularly Haruto. Despite her mischievous nature, Kitsune-san is not malevolent; her actions are more playful than harmful, and she gradually forms a bond with Haruto.

The story unfolds as Haruto navigates his daily life while dealing with Kitsune-san's antics. Her pranks range from harmless tricks to more elaborate schemes that often leave Haruto in awkward or humorous situations. Over time, their relationship evolves from one of annoyance and frustration to a more complex dynamic, with hints of romantic tension. Kitsune-san's presence in Haruto's life introduces him to a world of supernatural beings and events, adding a layer of fantasy to the otherwise mundane setting.

Supporting characters include other supernatural entities and Haruto's human acquaintances, who occasionally become entangled in Kitsune-san's schemes. These interactions provide additional comedic moments and contribute to the development of the main characters. The series balances its comedic elements with moments of introspection and emotional depth, particularly as Haruto and Kitsune-san's relationship deepens.

The manga explores themes of trust, companionship, and the blending of the ordinary with the extraordinary. Kitsune-san's playful nature serves as a catalyst for Haruto's personal growth, pushing him out of his comfort zone and challenging his perceptions of the world. The series maintains a lighthearted tone overall, with occasional forays into more serious or heartfelt moments, creating a well-rounded narrative that appeals to fans of both comedy and romance.