"Love Lab" is a romantic comedy manga series that centers on the lives of students at Fujisaki Girls' Academy, a prestigious all-girls school. The story primarily revolves around Riko Kurahashi, a tomboyish and athletic first-year student, and Natsuo Maki, the student council vice president known for her refined and elegant demeanor. Despite their contrasting personalities, the two form an unlikely friendship after Riko accidentally discovers Natsuo practicing romantic gestures with a pillow, mistaking it for a boyfriend. This leads to the creation of the "Love Lab," a secret club where the girls research and experiment with romantic techniques to prepare for future relationships.

The narrative explores the humorous and often chaotic situations that arise as Riko and Natsuo, along with their friends, attempt to understand the complexities of love and romance. The group includes Suzuyo Yuzuhara, the student council president who is overly enthusiastic about their experiments; Sayori Mizushima, a quiet and observant classmate; and Eno Shibasaki, a mischievous and sharp-tongued upperclassman. Together, they engage in various activities, such as practicing confession scenarios, studying dating simulators, and analyzing romantic tropes, often leading to comedic misunderstandings and heartfelt moments.

As the series progresses, the characters' relationships deepen, and their individual quirks and insecurities are revealed. Riko's lack of experience with romance contrasts with Natsuo's idealized notions of love, creating a dynamic interplay between their perspectives. The story balances lighthearted humor with moments of genuine emotional growth, as the girls navigate their friendships and personal challenges. The manga also incorporates themes of self-discovery, the importance of communication, and the value of embracing one's true self, all while maintaining a playful and engaging tone.