"Yajikita Gakuen Dōchūki F" is a comedic manga series that blends historical parody with modern-day school life. The story is set in Yajikita Academy, a high school where the students and faculty are caricatures of historical figures from Japan's Bakumatsu and Meiji periods. The central characters are based on prominent historical personalities such as Sakamoto Ryōma, Katsu Kaishū, and Okita Sōji, reimagined as high school students navigating the absurdities of school life.

The narrative revolves around the daily antics and misadventures of these characters as they interact with one another in a contemporary school setting. Sakamoto Ryōma, the protagonist, is portrayed as a laid-back yet determined student who often finds himself caught in bizarre situations. Katsu Kaishū, the school's principal, serves as a mentor figure, while Okita Sōji, a member of the school's disciplinary committee, frequently clashes with Ryōma and others due to his strict and often overzealous nature. Other historical figures, such as Hijikata Toshizō and Kondō Isami, are reimagined as members of the school's faculty or student body, adding to the chaotic and humorous atmosphere.

The plot is episodic, with each chapter focusing on a different comedic scenario, ranging from school festivals and sports competitions to absurd misunderstandings and exaggerated rivalries. The humor often stems from the juxtaposition of the characters' historical personas with their modern-day roles, creating a unique blend of satire and slapstick comedy. Despite the anachronistic setting, the series occasionally incorporates references to actual historical events, adding a layer of educational value to the humor.

The manga maintains a lighthearted tone throughout, with exaggerated character expressions and over-the-top situations driving the comedy. The interactions between the characters are central to the story, with their contrasting personalities and historical backgrounds providing ample material for humor. While the series does not delve deeply into serious themes or character development, it succeeds in delivering consistent entertainment through its clever use of historical parody and school-life tropes.