"Shinozaki Himeno no Koigokoro Q&A" centers on Himeno Shinozaki, a high school student who writes an anonymous advice column for her school newspaper under the pseudonym "Miss Lonely Heart." Despite her expertise in offering relationship advice to others, Himeno struggles with her own romantic feelings and insecurities. Her column becomes increasingly popular, leading to a variety of students seeking her guidance on love and personal dilemmas. However, her anonymity complicates matters when she begins to develop feelings for a classmate, Yuuto Kurosaki, who is unaware of her dual identity.

The narrative explores the challenges Himeno faces as she balances her role as an advice columnist with her personal life. Her interactions with Yuuto are marked by misunderstandings and missed opportunities, as she hesitates to reveal her true feelings. Meanwhile, her advice to others often reflects her own internal conflicts, creating a parallel between her professional and personal struggles. The story delves into themes of self-discovery, communication, and the complexities of young love, as Himeno navigates her relationships with classmates, friends, and herself.

Supporting characters include Himeno’s close friends, who provide emotional support and occasionally complicate her situation, as well as other students who seek her advice. The manga’s episodic structure allows for a variety of subplots, each focusing on different characters and their romantic or personal issues, while maintaining a central focus on Himeno’s growth and her evolving relationship with Yuuto. The series blends humor, heartfelt moments, and relatable scenarios, offering a nuanced portrayal of teenage emotions and relationships.