"Hataraki Man" centers on Hiroko Matsukata, a 28-year-old editor working at a weekly magazine called Jidai in Tokyo. The series explores her professional and personal life, highlighting the challenges she faces in a demanding workplace. Hiroko is dedicated, hardworking, and often sacrifices her personal time to meet tight deadlines, embodying the concept of a "hataraki man" (working man). Her job requires her to juggle multiple tasks, including managing writers, negotiating with printers, and ensuring the magazine's content meets high standards. Despite her competence, she often feels the pressure of being a woman in a male-dominated industry, navigating workplace dynamics and societal expectations.

The narrative delves into Hiroko's relationships with her colleagues, such as her supportive but competitive coworker, Tanaka, and her boss, Shimada, who recognizes her talent but also pushes her to her limits. Hiroko's personal life is equally complex, as she struggles to balance her career with her romantic relationship with her boyfriend, Hiroshi, who works in a different field and often feels neglected due to her long hours. The series portrays the tension between her professional ambitions and her desire for a fulfilling personal life.

Throughout the story, Hiroko encounters various challenges, including conflicts with writers, ethical dilemmas in journalism, and the constant pressure to deliver quality content under tight deadlines. The manga also touches on broader themes such as gender roles in the workplace, the sacrifices required for career success, and the importance of finding a balance between work and personal life. Hiroko's journey is marked by moments of self-reflection, growth, and resilience as she navigates the complexities of her career and relationships. The series provides a realistic and nuanced portrayal of the modern workplace, offering insights into the struggles and triumphs of a dedicated professional.