"Hidari no Me no Akuryō" is a supernatural mystery manga that revolves around the life of Itsuki Iba, a high school student who possesses a cursed left eye capable of seeing malevolent spirits and predicting death. This ability, known as the "Evil Eye," has plagued Itsuki since childhood, isolating him from others due to the fear and danger it brings. The story begins with Itsuki attempting to live a normal life despite his curse, but his efforts are disrupted when he encounters a series of supernatural events tied to his eye.

The narrative unfolds as Itsuki becomes entangled with a mysterious girl named Misao, who claims to have a connection to his cursed eye. Misao reveals that the Evil Eye is not merely a curse but a powerful tool that can be used to combat malevolent spirits. Together, they form an uneasy alliance to investigate and confront the dark forces that threaten both their lives and the world around them. As the story progresses, Itsuki learns more about the origins of his curse and the hidden history of the Evil Eye, which is tied to a lineage of individuals who have wielded its power throughout history.

The manga delves into themes of fate, sacrifice, and the struggle between good and evil. Itsuki is portrayed as a reluctant hero, burdened by the weight of his abilities and the moral dilemmas they present. Misao, on the other hand, serves as a catalyst for his growth, pushing him to confront his fears and embrace his role in the supernatural conflict. The relationship between the two characters evolves as they face increasingly dangerous adversaries, including vengeful spirits, ancient curses, and other individuals who seek to exploit the power of the Evil Eye for their own purposes.

The plot is structured around episodic encounters with supernatural phenomena, each revealing more about the world of the Evil Eye and the characters' pasts. These encounters are often tied to urban legends, folklore, and historical events, adding depth to the story's mythology. As Itsuki and Misao uncover the truth behind the Evil Eye, they are forced to make difficult choices that test their resolve and challenge their understanding of right and wrong.

The manga balances action, suspense, and emotional drama, with a focus on character development and world-building. Itsuki's journey from a reluctant outcast to a determined protector is central to the narrative, while Misao's enigmatic nature and her own connection to the Evil Eye add layers of intrigue. The series explores the consequences of wielding supernatural power and the personal cost of confronting darkness, creating a compelling and immersive story.