In a world filled with malicious individuals ranging from petty thieves to dangerous sociopaths, the victims of these crimes often find themselves overwhelmed by anger and a sense of helplessness. When the law fails to provide justice and their suffering becomes unbearable, these tormented souls can call upon a mysterious woman known only as the owner of the Revenge Shop, Uramiya. For a fair price, the Uramiya guarantees to execute the vengeance her clients seek, which can range from financially ruining a target and destroying their social reputation to taking their very lives.

The central figure of the series is Houjou Shiori, the enigmatic proprietress of the shop. Her true name, age, and past are shrouded in mystery, rarely mentioned throughout the story. She is a cold-blooded and calculating strategist who is highly manipulative and claims to despise the word justice, yet she operates with a personal code that is gradually revealed as the narrative unfolds. As the series progresses, her hidden kindness surfaces, though it is often masked behind seemingly selfish motives such as securing a skilled information agent or recruiting a talented individual to work off a debt. She is supported by a recurring team of operatives who initially appear as minor characters but become regular members of her crew. This team includes a tech-genius information broker who serves as her primary hacker, an eccentric otaku with a vivid imagination and athletic abilities, a handsome and narcissistic male host whose charm is useful for seduction-based missions, a high school girl who becomes an indentured assistant after avenging her abuse by her stepfather, and a shady doctor with a creepy demeanor.

The story is set in a realistic contemporary Japanese urban environment, focusing on the dark underbelly of society where crimes like credit card scams, identity theft, bullying, and sexual violence occur. The manga is largely episodic, with most cases being resolved within a single chapter, though some span multiple chapters. Each episode follows a satisfying formula where a terrible person who has evaded legal consequences is methodically punished by Uramiya and her team using psychological manipulation, complex traps, and indirect methods that leave no trace for the police. The antagonists are often portrayed as one-dimensional villains whose faces distort with malice, and the series handles dark adult subjects such as murder, prostitution, and suicide without subtlety.

Despite the episodic nature, a notable overarching narrative arc builds towards the final volumes. This long-running plot involves a cult organization that functions by scamming people, which serves as the primary recurring antagonist and final boss of the series. Throughout the manga, hints are dropped that the heroine's mysterious past is directly connected to this cult and its leader, with her actions over the course of the story being a calculated preparation for a final confrontation that is resolved in the last volume. The series also features a branch office in Okinawa, and the police, particularly a suspicious detective, are present as recurring obstacles.

The manga known as Uramiya Honpo was written and illustrated by Shoushou Kurihara. While the user query asks for Uramiya Honpo Stream, no reliable information could be found for a manga with that specific title. The confirmed and related work is Uramiya Honpo and its sequel, Uramiya Honpo: Sukuruma Fuusuke, which follows a government office worker named Sukuruma Fusuke who works part-time for the Revenge Shop alongside a team of skilled agents.