A male university student who dies a virgin experiences a time slip and a sex change, waking up in the body of his own middle school self—only now as a girl. Now called Nagara Ayano, this middle school girl possesses the memories and frustrated desires of her former adult male self. Her single-minded goal is to finally lose her virginity, a mission she pursues with an aggressive and unfiltered bluntness that creates a string of outrageous, awkward, and darkly comedic situations.

The protagonist grows up in a familiar Japanese middle school environment, but her internal perspective transforms everyday social interactions into a high-stakes battlefield for her objective. She approaches classmates, acquaintances, and other potential partners with startling directness, devoid of the typical adolescent shyness. The central conflict arises from the clash between her desperate, purely physical pursuit of a first sexual experience and the complex reality of human relationships that include emotional connection, consent, and unexpected consequences.

Over the course of the story, the protagonist encounters a variety of people who challenge her shallow understanding of sex and intimacy. She often assumes the worst in others, approaching individuals who seem dangerous or predatory, only to find that they often possess a hidden decency. When these encounters lead to rejection, she experiences a sadness that reveals what she truly craves is not just a biological act but a genuine connection and an end to profound loneliness. Conversely, when she does attract genuinely malicious individuals, she is typically rescued before any serious harm can occur, leading to moments of realization that violent or loveless sex is not what she actually wants. The plot uses wacky, exaggerated humor to explore themes of social isolation, self-hatred, and the mistaken belief that sex alone is a cure for a lack of love. As the manga continues, these thinly veiled conflicts expose the protagonist's internal struggle, culminating in an ending where a sexual union represents a form of self-acceptance, though she remains in her female body and her original goal remains, fittingly, still unfulfilled.