"Call the Name of the Night" is a fantasy manga set in a world where mysterious creatures known as "Night" exist, capable of consuming light and plunging areas into darkness. The narrative centers on Mira, a young girl afflicted with a rare condition called "Night Sickness," which causes her to emit darkness uncontrollably. Her condition isolates her from society, as the darkness she produces is feared and misunderstood. To protect others, Mira lives in seclusion with her caretaker, a man named Tama, who is deeply devoted to her well-being.

The story begins when Mira and Tama encounter a traveling doctor named Rei, who claims to have knowledge about Night Sickness. Rei offers to help Mira, suggesting that her condition might be curable. This encounter sets the trio on a journey to uncover the truth behind Mira's affliction and the origins of the Night. Along the way, they face various challenges, including hostile Night creatures, societal prejudice, and the lingering mysteries of Mira's past.

As the narrative progresses, it becomes clear that Mira's condition is tied to a larger, more complex phenomenon involving the balance between light and darkness in the world. The story explores themes of isolation, acceptance, and the search for identity, as Mira grapples with her place in a world that fears her. Tama's unwavering loyalty and Rei's enigmatic motivations add layers of intrigue, as their relationships with Mira evolve amidst the unfolding mystery.

The manga balances episodic adventures with an overarching plot, gradually revealing the connections between Mira's condition, the Night creatures, and the world's history. The interplay between the characters' personal struggles and the broader fantasy elements creates a compelling narrative that blends emotional depth with imaginative world-building.