"Bokusatsu Tenshi Dokuro-chan" is a manga series that blends comedy, fantasy, and ecchi elements, centered around the life of Sakura Kusakabe, an ordinary middle school student. The story begins when Dokuro Mitsukai, a pink-haired angel from the future, suddenly appears in Sakura's life. Dokuro claims to be a member of an angelic task force sent to monitor Sakuro due to his future actions. In the future, Sakura inadvertently creates a technology that halts the aging process in women, leading to societal upheaval. To prevent this, Dokuro is tasked with either killing Sakura or ensuring he never develops the technology.

Dokuro wields a spiked bat called Excalibolg, which she uses to repeatedly kill Sakura in gruesome and over-the-top ways. However, she also carries a magical item called the Pipiru Piru Piru Pipiru Pi, which resurrects him immediately after each death. This cycle of violence and resurrection becomes a recurring comedic motif throughout the series. Despite her violent tendencies, Dokuro harbors romantic feelings for Sakura, which adds a layer of complexity to her mission.

Another key character is Sabato, Dokuro's rival and fellow angel, who is more ruthless and determined to eliminate Sakura outright. Sabato's methods are less restrained, often leading to chaotic confrontations with Dokuro. The dynamic between Dokuro, Sabato, and Sakura drives much of the series' humor and conflict. The narrative frequently shifts between absurd, slapstick comedy and moments of lighthearted romance, with Dokuro's unpredictable behavior and Sakura's exasperated reactions forming the core of the story.

The manga explores themes of fate, morality, and the consequences of technological advancement, albeit in a comedic and exaggerated manner. The interactions between the characters, particularly Dokuro's attempts to balance her mission with her growing affection for Sakura, provide the series' emotional backbone. The story maintains a fast-paced, episodic structure, with each chapter introducing new absurd scenarios or challenges for the characters to navigate. The blend of dark humor, fantastical elements, and occasional heartfelt moments creates a unique tone that defines the series.