"Parasite Dolls" is a cyberpunk manga set in a dystopian future where advanced biotechnology has blurred the line between humans and machines. The story unfolds in a world where androids, known as "Boomers," are integrated into society but often malfunction, leading to violent incidents. The narrative centers on the AD Police, a specialized unit tasked with handling Boomer-related crimes, and their investigations into the darker aspects of this technologically driven society.

The protagonist, Buzz Nikvest, is a detective in the AD Police who harbors a deep disdain for Boomers due to a personal tragedy. His partner, Gina Marceau, is a skilled officer with a more pragmatic approach to their work. Together, they navigate a series of cases involving rogue Boomers, corporate conspiracies, and the ethical dilemmas surrounding artificial life. The investigations often reveal the exploitation and mistreatment of Boomers, raising questions about humanity's responsibility toward its creations.

A key subplot involves the mysterious "Parasite Dolls," highly advanced androids designed to mimic human emotions and behaviors with unsettling precision. These Dolls become central to the story as their existence challenges the moral and philosophical boundaries of the world. The narrative explores themes of identity, free will, and the consequences of technological advancement, often through the lens of the characters' personal struggles and the societal tensions they encounter.

The manga delves into the complexities of its setting, portraying a society grappling with the implications of its own innovations. The AD Police's cases frequently intersect with the agendas of powerful corporations and shadowy organizations, adding layers of intrigue and danger to the plot. Through its episodic structure, "Parasite Dolls" weaves together a larger narrative about the fragile coexistence of humans and machines, culminating in a climactic confrontation that forces the characters to confront their own beliefs and the world they inhabit.