"Ichigoki's Under Control!!" is a science-fiction comedy manga that revolves around the life of Ichigoki, a high school student who becomes the unwilling subject of a bizarre experiment. After a freak accident involving a mysterious organization, Ichigoki is transformed into a human-robot hybrid, with his body now controlled by a remote device. This device falls into the hands of his classmate, Kousaku Matsuo, who uses it to manipulate Ichigoki's actions, often for comedic or self-serving purposes.

The narrative explores the dynamic between Ichigoki and Kousaku, as the latter frequently exploits Ichigoki's robotic abilities for personal gain, leading to chaotic and humorous situations. Despite his predicament, Ichigoki retains his human emotions and desires, creating a constant internal struggle between his robotic functions and his humanity. The story also introduces other characters, such as Ichigoki's love interest, Aoi, who remains unaware of his transformation, and various members of the organization responsible for his condition, who occasionally reappear to complicate matters.

The manga blends slapstick humor with moments of introspection, as Ichigoki grapples with his dual identity and the ethical implications of his transformation. The plot is driven by episodic adventures, often involving Kousaku's schemes, Ichigoki's attempts to regain control of his life, and the occasional interference of the shadowy organization. The series balances its comedic tone with underlying themes of autonomy, identity, and the consequences of technological experimentation, making it a unique addition to the science-fiction comedy genre.