"Moteki" centers on Yukiyo Fujimoto, a 30-year-old office worker who has struggled with romantic relationships throughout his life. Despite his lack of success with women, Yukiyo's life takes an unexpected turn when he suddenly becomes the object of affection for multiple women. This sudden surge in attention, referred to as a "moteki" or "popular period," leaves him both bewildered and overwhelmed as he navigates the complexities of these newfound romantic opportunities.

The story begins with Yukiyo reconnecting with Aki Yamamoto, a former coworker who had previously shown no interest in him. Aki's sudden flirtatious behavior sparks confusion and curiosity in Yukiyo, who is unaccustomed to such attention. As the narrative progresses, other women from Yukiyo's past and present enter the picture, including his high school crush, a younger coworker, and a former classmate. Each woman represents a different facet of Yukiyo's life, forcing him to confront his insecurities, past regrets, and the societal pressures surrounding relationships and masculinity.

Yukiyo's journey is marked by a mix of humor, introspection, and awkwardness as he grapples with his self-doubt and the moral dilemmas posed by his newfound popularity. The series explores themes of self-worth, the fleeting nature of romantic opportunities, and the impact of societal expectations on personal relationships. The interactions between Yukiyo and the women in his life are often tinged with ambiguity, reflecting the complexities of modern romance and the challenges of communication.

The supporting characters, including Yukiyo's friends and coworkers, provide additional layers to the story, offering contrasting perspectives on love, success, and personal growth. The narrative balances comedic moments with poignant reflections on loneliness and the human desire for connection, creating a multifaceted portrayal of Yukiyo's experiences.

As the story unfolds, Yukiyo must decide how to navigate his "moteki" period, weighing the potential for meaningful relationships against the fear of rejection and the uncertainty of his own desires. The series ultimately presents a nuanced exploration of romantic dynamics, personal growth, and the unpredictable nature of love.