"The Rokudo Rounds" centers on Rokudo Tousuke, a high school student who inherits a cursed family heirloom known as the Rokudo Rounds, a set of six magical beads. These beads grant him the ability to attract women, but they also come with a significant drawback: the curse causes misfortune to anyone who uses them. Rokudo, initially reluctant to embrace this power, finds himself entangled in a series of chaotic and often dangerous situations as the beads' influence begins to disrupt his life.

The narrative unfolds as Rokudo encounters various female characters, each with their own unique personalities and backstories, who are inexplicably drawn to him due to the beads' magic. Among them is Rindo Aisa, a strong-willed and independent girl who becomes one of the central figures in Rokudo's life. Despite the beads' curse, Rokudo gradually forms genuine bonds with these women, striving to protect them from the misfortunes that the beads bring.

As the story progresses, Rokudo learns more about the history of the Rokudo Rounds and the dark forces tied to them. The beads are revealed to be connected to a malevolent entity known as the Rokudo Demon, which seeks to use Rokudo as a vessel to unleash chaos upon the world. This revelation sets the stage for a larger conflict, as Rokudo must confront not only the external threats posed by the demon but also the internal struggle of balancing his growing relationships with the responsibility of wielding the beads' power.

The series blends elements of comedy, romance, and supernatural action, with Rokudo's interactions with the female characters often leading to humorous and heartfelt moments. However, the underlying tension of the curse and the looming threat of the Rokudo Demon add a layer of urgency and drama to the narrative. Rokudo's journey is one of self-discovery, as he learns to navigate the complexities of his newfound abilities while striving to protect those he cares about from the dangers that follow him.