"After-School Hanako-kun" is a spin-off manga series set in the same universe as "Toilet-Bound Hanako-kun," focusing on the daily lives and humorous misadventures of the supernatural entities and students at Kamome Academy. The narrative revolves around Hanako-kun, the ghostly seventh wonder of the school, and his interactions with Nene Yashiro, a first-year student who becomes his assistant. The series explores their quirky relationship alongside other characters, including Kou Minamoto, a young exorcist, and Mitsuba Sousuke, a ghost with a penchant for photography.

The plot is episodic, with each chapter presenting self-contained stories that delve into the supernatural occurrences at Kamome Academy. These incidents often involve the school's seven mysteries, each of which is a ghost or spirit with unique abilities and personalities. Hanako-kun and Yashiro frequently find themselves mediating conflicts between these entities or dealing with the unintended consequences of their powers. The tone is lighter and more comedic compared to the main series, emphasizing slice-of-life moments and character-driven humor.

Key recurring themes include friendship, the blending of the human and supernatural worlds, and the personal struggles of the characters. Hanako-kun’s mischievous yet protective nature contrasts with Yashiro’s earnest and sometimes naive demeanor, creating a dynamic that drives much of the series’ charm. Kou’s determination to exorcise Hanako-kun while grappling with his own moral dilemmas adds depth to the narrative, while Mitsuba’s antics provide comic relief and occasional poignant moments.

The series expands on the lore of Kamome Academy, offering glimpses into the backstories of the seven mysteries and their relationships with one another. It also introduces new characters and scenarios that enrich the world-building. Despite its comedic focus, "After-School Hanako-kun" occasionally touches on darker themes, such as the nature of existence and the emotional burdens carried by the supernatural beings. This balance of humor and introspection makes it a compelling addition to the franchise, appealing to fans of the original series while standing on its own as a lighthearted exploration of its characters and setting.