"Chihiro-kun Only Has Eyes For Me" centers on the life of Chihiro, a high school student who possesses a unique and unsettling ability: his eyes naturally draw people in, causing them to fall deeply in love with him. This phenomenon occurs regardless of his intentions, leading to constant romantic attention from those around him. Despite his charm, Chihiro is introverted and struggles with the overwhelming consequences of his ability, as it disrupts his daily life and relationships.

The narrative explores Chihiro's interactions with his classmates, particularly focusing on his childhood friend, Yuzuki, who is one of the few people immune to his captivating gaze. Yuzuki serves as a grounding presence in Chihiro's life, offering support and understanding as he navigates the chaos caused by his ability. Their relationship evolves as they confront the challenges posed by Chihiro's condition, including jealousy, misunderstandings, and the emotional toll of unrequited love from others.

Throughout the series, Chihiro grapples with the moral implications of his power, questioning whether the affection he receives is genuine or merely a byproduct of his eyes. The story delves into themes of identity, autonomy, and the nature of love, as Chihiro seeks to understand himself and his place in the world. The manga balances lighthearted moments with deeper emotional exploration, creating a narrative that is both engaging and thought-provoking. The characters' growth and the dynamics of their relationships drive the plot, offering a blend of romance, comedy, and introspection.