"Full Clearing Another World under a Goddess with Zero Believers" centers on Makoto Takatsuki, an ordinary high school student who is transported to a fantasy world alongside his classmates. In this new world, individuals are granted unique skills and divine blessings based on their potential and faith. However, Makoto receives a seemingly weak skill called "Sleeping Hero," which allows him to gain strength and abilities while sleeping, and is blessed by a minor goddess, Noah, who has no followers. This makes him an outlier among his peers, who are blessed by more powerful deities and possess stronger abilities.

As the story progresses, Makoto is initially dismissed and underestimated due to his low-status blessing and seemingly unimpressive skill. However, he leverages his resourcefulness, adaptability, and the hidden potential of his abilities to survive and grow stronger. Along the way, he forms alliances with other outcasts and misfits, including a beastkin warrior named Sasa and a cursed princess named Lucy. Together, they navigate the challenges of the fantasy world, which includes battling monsters, uncovering political intrigue, and confronting the prejudices of a society that values divine favor above all else.

The narrative explores themes of perseverance, self-reliance, and the value of overlooked individuals. Makoto’s journey is marked by his determination to prove his worth despite his initial disadvantages, as well as his growing bond with Noah, the goddess who believes in him despite her own lack of followers. The story balances action, character development, and world-building, gradually revealing the complexities of the fantasy world and the roles its inhabitants play in shaping its future.