"Kemono Jihen" is a supernatural action manga set in a world where humans coexist with kemono, creatures that possess animalistic traits and abilities. The story begins in a rural village where a boy named Kabane Kusaka works at his aunt and uncle's inn, enduring mistreatment and isolation due to his mysterious origins and unusual strength. His life changes when a detective named Kohachi Inugami visits the village to investigate a series of strange incidents involving animal carcasses. Inugami, who specializes in kemono-related cases, quickly recognizes Kabane as a half-human, half-kemono hybrid with immense potential.

Inugami invites Kabane to join his detective agency in Tokyo, where he works alongside other kemono and hybrids to solve supernatural cases. Kabane meets Shiki Tademaru, a reserved and intelligent boy who wields a powerful cursed sword, and Akira, a cheerful and energetic fox kemono with the ability to manipulate fire. Together, they form a team tasked with investigating and resolving conflicts involving kemono, often uncovering deeper mysteries tied to their own pasts.

As the story progresses, the team faces increasingly dangerous adversaries, including rogue kemono and powerful organizations with hidden agendas. Kabane learns more about his origins, discovering that he is a rare type of kemono known as a "Dorotabo," a creature born from the resentment of the dead. This revelation ties him to a larger conflict involving the Kemono Council, a governing body of kemono, and the mysterious experiments conducted by a group called the "Hakumei." The Hakumei seek to exploit kemono abilities for their own purposes, leading to confrontations that test the bonds between Kabane and his friends.

The narrative explores themes of identity, belonging, and the coexistence of humans and kemono, as the characters grapple with their dual natures and the societal prejudices they face. Kabane's journey is central to the story, as he strives to understand his place in the world while protecting those he cares about. The manga balances action-packed battles with moments of introspection, delving into the personal struggles and growth of each character. Through its intricate world-building and layered plot, "Kemono Jihen" presents a compelling tale of supernatural intrigue and camaraderie.