"Run on Your New Legs" centers on Kikuzato Iwao, a former high school track star whose life takes a dramatic turn after losing his leg in an accident. Struggling to adapt to his new reality, Iwao withdraws from society, feeling disconnected from his dreams and ambitions. His life changes when he encounters Shibuya, a prosthetist who introduces him to the world of prosthetic limbs and the possibility of running again. Shibuya’s passion for helping amputees reignites Iwao’s determination, and he begins to explore the potential of his new prosthetic leg.

The narrative delves into Iwao’s journey of physical and emotional rehabilitation as he relearns how to run, facing both the technical challenges of using a prosthetic and the psychological hurdles of self-doubt and societal stigma. Along the way, he meets other individuals with disabilities, each with their own stories and struggles, which broaden his perspective and deepen his resolve. The story emphasizes themes of perseverance, resilience, and the redefinition of personal identity in the face of adversity.

Iwao’s relationship with Shibuya serves as a cornerstone of the plot, with the prosthetist acting as both mentor and motivator. Their interactions highlight the importance of support systems and the transformative power of empathy and encouragement. As Iwao progresses, he begins to compete in para-athletics, rediscovering his passion for running and redefining what it means to be an athlete. The manga balances its focus on Iwao’s personal growth with broader discussions about disability, accessibility, and the societal perceptions of those with physical limitations.

The artwork complements the narrative by capturing the intensity of Iwao’s training, the intricacies of prosthetic technology, and the emotional weight of his journey. The series avoids melodrama, instead presenting a grounded and realistic portrayal of life after amputation, making it both informative and inspiring. Through its exploration of Iwao’s transformation, "Run on Your New Legs" offers a compelling and heartfelt story about overcoming obstacles and finding new purpose.