"Escha & Logy no Atelier: Tasogare no Sora no Renkinjutsushi" is a manga adaptation of the video game "Atelier Escha & Logy: Alchemists of the Dusk Sky." The story is set in a world where the once-thriving civilization has declined, leaving behind ruins and mysterious artifacts. The narrative centers on two alchemists, Escha Malier and Logix "Logy" Fiscario, who work for the Colseit Development Department, a government organization tasked with exploring ruins and reviving lost technologies.

Escha, a cheerful and optimistic young alchemist, is paired with Logy, a reserved and methodical alchemist from a distant city. Together, they embark on missions to investigate ancient ruins, uncover the secrets of alchemy, and develop new technologies to improve their world. Their work involves synthesizing items, battling hostile creatures, and solving the mysteries of the Dusk, a phenomenon that has caused the world's decline.

As the story progresses, Escha and Logy encounter various challenges, including rival organizations, personal struggles, and the enigmatic nature of the Dusk itself. Their journey is intertwined with the lives of their colleagues and friends, such as Awin Sidelet, a skilled engineer, and Threia Hazelgrimm, a researcher with a deep interest in the ruins. The narrative explores themes of collaboration, discovery, and the balance between progress and preservation.

The manga maintains a focus on the characters' growth, both individually and as a team, while delving into the lore of the Dusk and the remnants of the ancient civilization. The plot is driven by their efforts to uncover the truth behind the world's decline and their role in shaping its future. Through their adventures, Escha and Logy confront moral dilemmas, forge strong bonds, and strive to bring hope to their fading world.