"Comic Girls" centers on Kaoruko Moeta, a high school student and aspiring manga artist who struggles with self-doubt about her work. Despite her passion for creating manga, her series is often criticized for being too childish, leading her to enroll in a dormitory specifically for female manga creators. The dorm, named Koisuru Henshuusha, houses other young artists, each specializing in different genres and facing their own creative challenges.

Kaoruko, nicknamed "Kaos," shares the dorm with Tsubasa Katsuki, a confident and energetic creator of shonen manga; Koyume Koizuka, a shy and romantic shojo manga artist; and Ruki Irokawa, a reserved and mature artist known for her seinen work. The series explores their daily lives as they navigate the pressures of deadlines, creative blocks, and personal insecurities while supporting one another in their artistic endeavors.

The narrative emphasizes the camaraderie and growth of the characters as they balance their school lives with their professional aspirations. Kaoruko’s journey is particularly central, as she learns to embrace her unique style and gain confidence in her abilities. The interactions between the characters highlight the diverse perspectives and challenges within the manga industry, from the competitive nature of shonen to the emotional depth required for shojo and the nuanced storytelling of seinen.

Throughout the series, the characters participate in various activities, such as attending manga conventions, collaborating on projects, and seeking feedback from editors. These experiences provide insight into the creative process and the realities of being a manga artist. The story also incorporates lighthearted moments, humor, and slice-of-life elements, creating a balance between the struggles and joys of pursuing a creative career.

"Comic Girls" offers a detailed look at the lives of young manga creators, blending personal growth, friendship, and the intricacies of the manga industry into a cohesive narrative. The series provides an accessible and engaging portrayal of the challenges and rewards of artistic expression, making it a relatable and informative read for fans of manga and aspiring creators alike.