"Zombie of Mars" is a science fiction horror manga set on the colonized planet of Mars, where humanity has established a thriving society. The narrative begins with the sudden outbreak of a mysterious virus that reanimates the dead, turning them into aggressive, flesh-hungry zombies. The story centers on a group of survivors, including Kaito, a former engineer with a troubled past, and Aya, a resourceful medical researcher determined to find a cure. As the infection spreads rapidly across the Martian colonies, the group must navigate the desolate, high-tech urban landscapes and underground facilities to uncover the origins of the virus while evading both the undead and the increasingly unstable remnants of the human population.

The plot delves into the ethical dilemmas of scientific experimentation, as it is revealed that the virus was inadvertently created by a secretive biotech corporation attempting to develop advanced medical treatments. The survivors encounter various factions, including rogue scientists, militarized security forces, and desperate civilians, each with conflicting agendas. Tensions rise as the group struggles to maintain trust and cooperation while facing constant threats from the infected and the harsh Martian environment.

Key characters include Dr. Haruto, a morally ambiguous scientist who holds critical information about the virus, and Rina, a young girl with a mysterious immunity that becomes central to the search for a cure. The narrative explores themes of survival, human resilience, and the consequences of unchecked technological ambition. As the survivors uncover more about the virus and its origins, they are forced to confront the possibility that the outbreak may have been orchestrated for purposes beyond their understanding. The story builds toward a climactic confrontation with the corporation responsible, culminating in a desperate bid to escape Mars and prevent the virus from reaching Earth.